Article
An ABC transporter involved in the control of streptomycin production in Streptomyces griseus.
FEMS microbiology letters - 1 Jul 2016
Takano Hideaki, Toriumi Naoe, Hirata Mariko, Amano Taisuke, Ohya Takaaki, Shimada Reona, Kusada Hiroyuki, Amano Sho-Ichi, Matsuda Ko-Ichi, Beppu Teruhiko, Ueda Kenji
Abstract excerpt
We screened for a gene that inhibits streptomycin production in Streptomyces griseus when it is introduced on a high-copy-number plasmid pIJ702, and obtained a plasmid pKM545. The introduction of pKM545 abolished streptomycin production on all media tested including YMP-sugar and Nutrient broth. S1 protection analysis demonstrated that the introduction of this plasmid downregulated the transcriptional activity of...
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