Article
Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice.
PLoS biology - 1 Aug 2004
Bygrave Anne E, Rose Kirsten L, Cortes-Hernandez Josefina, Warren Joanna, Rigby Robert J, Cook H Terence, Walport Mark J, Vyse Timothy J, Botto Marina
Abstract excerpt
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of gene-targeted mice have been reported to develop SLE, implicating the null genes in the causation of disease. However, hybrid strains between 129 and C57BL/6 mice, widely used in the generation of gene-targeted mice, develop spontaneous autoimmunity. Furthermore, the...
Topics
- Animals
- Autoimmunity
- Cell Nucleus
- Chromosome Mapping
- Cohort Studies
- Disease Models, Animal
- Epistasis, Genetic
- Female
- Gene Targeting
- Genetic Linkage
- Genetic Predisposition to Disease
- Genome
- Genotype