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Article

Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice.

PLoS biology - 1 Aug 2004

Bygrave Anne E, Rose Kirsten L, Cortes-Hernandez Josefina, Warren Joanna, Rigby Robert J, Cook H Terence, Walport Mark J, Vyse Timothy J, Botto Marina

Abstract excerpt

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of gene-targeted mice have been reported to develop SLE, implicating the null genes in the causation of disease. However, hybrid strains between 129 and C57BL/6 mice, widely used in the generation of gene-targeted mice, develop spontaneous autoimmunity. Furthermore, the...

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Identifiers

PMID: 15314659
DOI: 10.1371/journal.pbio.0020243
PMCID: PMC509305

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Source receipt: pubmed, retrieved 7 Sept 2026.

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