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Article

Expression of cellular FLIP by B cells is required for their participation in an immune response.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2010

Coffey Francis, Manser Tim

Abstract excerpt

High levels of the Fas-signaling antagonist cellular FLIP (cFLIP) in germinal center (GC) B cells suggests an important role for this factor during this stage of the T cell-dependent B cell immune response. To test this idea, we used mice with B cell-specific deletion of a floxed cFLIP allele. Although deletion of cFLIP did not alter their primary development, participation of cFLIP-deficient B cells in the...

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Source

Identifiers

PMID: 20335528
DOI: 10.4049/jimmunol.0903506

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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