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Article

Kaiso-deficient mice show resistance to intestinal cancer.

Molecular and cellular biology - 1 Jan 2006

Prokhortchouk Anna, Sansom Owen, Selfridge Jim, Caballero Isabel M, Salozhin Sergey, Aithozhina Dana, Cerchietti Leandro, Meng Fan Guo, Augenlicht Leonard H, Mariadason John M, Hendrich Brian, Melnick Ari, Prokhortchouk Egor, Clarke Alan, Bird Adrian

Abstract excerpt

Kaiso is a BTB domain protein that associates with the signaling molecule p120-catenin and binds to the methylated sequence mCGmCG or the nonmethylated sequence CTGCNA to modulate transcription. In Xenopus laevis, xKaiso deficiency leads to embryonic death accompanied by premature gene activation in blastulae and upregulation of the xWnt11 gene. Kaiso has also been proposed to play an essential role in mammalian...

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Identifiers

PMID: 16354691
DOI: 10.1128/MCB.26.1.199-208.2006
PMCID: PMC1317619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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