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Article

The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.

The Journal of biological chemistry - 4 Dec 2009

Machida Yuichi J, Machida Yuka, Vashisht Ajay A, Wohlschlegel James A, Dutta Anindya

Abstract excerpt

The deubiquitinating enzyme BRCA1-associated protein 1 (BAP1) possesses growth inhibitory activity and functions as a tumor suppressor. In this study we report that BAP1 also plays positive roles in cell proliferation. BAP1 depletion by RNAi inhibits cell proliferation as does overexpression of a dominant negative mutant of BAP1. Mass spectrometry analyses of copurified proteins revealed that BAP1 is associated...

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Share to Cell Cycle
Share to Chromatin
Share to Host Cell Factor C1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mass Spectrometry

Share to Protein Processing, Post-Translational

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Source

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Identifiers

PMID: 19815555
DOI: 10.1074/jbc.M109.046755
PMCID: PMC2797188

Genes

BAP1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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