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Article

BAP1 Is a Novel Target in HPV-Negative Head and Neck Cancer

7 Nov 2017

Abstract excerpt

Abstract Purpose: This study examined the potential role of the nuclear deubiquitinating enzyme BRCA1-associated protein-1 (BAP1) in radioresistance in head and neck squamous cell cancer (HNSCC). Experimental Design: We overexpressed, knocked down, and rescued BAP1 expression in six HNSCC cell lines, three human papillomavirus (HPV)–negative and three HPV-positive, and examined the effects on radiosensitivity in...

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PMID: 29113987
DOI: 10.1158/1078-0432.ccr-17-1573

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