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The Werner Syndrome Helicase/Exonuclease Processes Mobile D-Loops through Branch Migration and Degradation

12 Mar 2009

Abstract excerpt

RecQ DNA helicases are critical for preserving genome integrity. Of the five RecQ family members identified in humans, only the Werner syndrome protein (WRN) possesses exonuclease activity. Loss of WRN causes the progeroid disorder Werner syndrome which is marked by cancer predisposition. Cellular evidence indicates that WRN disrupts potentially deleterious intermediates in homologous recombination (HR) that...

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PMID: 19283071
DOI: 10.1371/journal.pone.0004825

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Related research

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The Werner Syndrome Helicase/Exonuclease Processes Mobile D-Loops through Branch Migration and DegradationPMID 19283071Read ↗

Replication Protein A Stimulates the Werner Syndrome Protein Branch Migration ActivitySemantic proximity Read ↗

Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome ProteinSemantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.Semantic proximity Read ↗

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structuresSemantic proximity Read ↗

WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structuresSemantic proximity Read ↗

Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loopsSemantic proximity Read ↗

WRN regulates pathway choice between classical and alternative non-homologous end joiningSemantic proximity Read ↗

Mismatch repair inhibits homeologous recombination via coordinated directional unwinding of trapped DNA structures.Semantic proximity Read ↗

Processing of branched DNA intermediates by a complex of human FEN-1 and PCNASemantic proximity Read ↗

The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.Semantic proximity Read ↗

Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicaseSemantic proximity Read ↗

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