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Article

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

10 May 2012

Abstract excerpt

Werner's syndrome (WS) and Bloom's syndrome (BS) are cancer predisposition disorders caused by loss of function of the RecQ helicases WRN or BLM, respectively. BS and WS are characterized by replication defects, hyperrecombination events and chromosomal aberrations, which are hallmarks of cancer. Inefficient replication of the G-rich telomeric strand contributes to chromosome aberrations in WS cells,...

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Share to DNA Repair Mechanisms
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PMID: 22576367
DOI: 10.1093/nar/gks407

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