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Article

Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops

30 Apr 2010

Abstract excerpt

Werner syndrome is an inherited human progeriod syndrome caused by mutations in the gene encoding the Werner Syndrome protein, WRN. It has both 3'-5' DNA helicase and exonuclease activities, and is suggested to have roles in many aspects of DNA metabolism, including DNA repair and telomere maintenance. The DNA-PK complex also functions in both DNA double strand break repair and telomere maintenance. Interaction...

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PMID: 20519774
DOI: 10.18632/aging.100141

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