Article
Genetic variation in CXCR4 and risk of chronic lymphocytic leukemia.
Blood - 26 Nov 2009
Crowther-Swanepoel Dalemari, Qureshi Mobshra, Dyer Martin J S, Matutes Estella, Dearden Claire, Catovsky Daniel, Houlston Richard S
Abstract excerpt
A genome-wide linkage scan has provided evidence for a chronic lymphocytic leukemia (CLL) susceptibility locus at 2q21 to which the chemokine receptor CXCR4 gene maps. Recent data provide some evidence for common variation in CXCR4 according to the polymorphic variant rs2228014 defining CLL risk. To examine the role of genetic variation in CXCR4 on CLL risk, we screened 188 familial CLL cases and 213 controls for...
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