Article
Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.
Blood - 10 Feb 2011
Slager Susan L, Rabe Kari G, Achenbach Sara J, Vachon Celine M, Goldin Lynn R, Strom Sara S, Lanasa Mark C, Spector Logan G, Rassenti Laura Z, Leis Jose F, Camp Nicola J, Glenn Martha, Kay Neil E, Cunningham Julie M, Hanson Curtis A, Marti Gerald E, Weinberg J Brice, Morrison Vicki A, Link Brian K, Call Timothy G, Caporaso Neil E, Cerhan James R
Abstract excerpt
Prior genome-wide association (GWA) studies have identified 10 susceptibility loci for risk of chronic lymphocytic leukemia (CLL). To identify additional loci, we performed a GWA study in 407 CLL cases (of which 102 had a family history of CLL) and 296 controls. Moreover, given the strong familial risk of CLL, we further subset our GWA analysis to the CLL cases with a family history of CLL to identify loci...
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