Article
Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro.
Molecular biology of the cell - 1 Dec 2009
Bae Gyu-Un, Yang Youn-Joo, Jiang Guoying, Hong Mingi, Lee Hye-Jin, Tessier-Lavigne Marc, Kang Jong-Sun, Krauss Robert S
Abstract excerpt
A variety of signaling pathways participate in the development of skeletal muscle, but the extracellular cues that regulate such pathways in myofiber formation are not well understood. Neogenin is a receptor for ligands of the netrin and repulsive guidance molecule (RGM) families involved in axon guidance. We reported previously that neogenin promoted myotube formation by C2C12 myoblasts in vitro and that the...
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