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Article

Progranulin regulates zebrafish muscle growth and regeneration through maintaining the pool of myogenic progenitor cells

31 Jan 2013

Abstract excerpt

Myogenic progenitor cell (MPC) is responsible for postembryonic muscle growth and regeneration. Progranulin (PGRN) is a pluripotent growth factor that is correlated with neuromuscular disease, which is characterised by denervation, leading to muscle atrophy with an abnormal quantity and functional ability of MPC. However, the role of PGRN in MPC biology has yet to be elucidated. Here, we show that knockdown of...

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PMID: 23378909
DOI: 10.1038/srep01176

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