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Article

Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β

27 Apr 2022

Abstract excerpt

Skeletal muscle regeneration is essential for maintaining muscle function in injury and muscular disease. Myogenesis plays key roles in forming new myofibers during the process. Here, through bioinformatic screen for the potential regulators of myogenesis from 5 independent microarray datasets, we identify an overlapping differentially expressed gene (DEG) optineurin (OPTN). Optn knockdown (KD) delays muscle...

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PMID: 35476671
DOI: 10.1371/journal.pbio.3001619

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