Article
Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 2007
Schuster-Gossler Karin, Cordes Ralf, Gossler Achim
Abstract excerpt
In vertebrates, skeletal myogenesis is initiated by the generation of myoblasts followed by their differentiation to myocytes and the formation of myofibers. The determination of myoblasts and their differentiation are controlled by muscle regulatory factors that are activated at specific stages during myogenesis. During late embryonic and fetal stages a distinct population of resident proliferating progenitor...
Topics
- Animals
- Base Sequence
- Cell Differentiation
- DNA Primers
- Female
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- Mice
- Mice, Knockout
- Mice, Transgenic
- Muscle Development
- Muscle, Skeletal
- Mutation
- Myoblasts, Skeletal