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Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling

6 Jun 2013

Abstract excerpt

Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta (TGFβ) superfamily. BMPs mediate a highly conserved signal transduction cascade through the type-I and type-II serine/threonine kinase receptors and intracellular Smad proteins, which regulate multiple developmental and homeostatic processes. Mutations in this pathway can cause various diseases in humans, such as skeletal disorders,...

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PMID: 23740870
DOI: 10.1002/mrd.22199

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