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Article

Genetic protection against hepatitis B virus conferred by CCR5Delta32: Evidence that CCR5 contributes to viral persistence.

Journal of virology - 1 Jan 2007

Thio Chloe L, Astemborski Jacquie, Bashirova Arman, Mosbruger Timothy, Greer Spencer, Witt Mallory D, Goedert James J, Hilgartner Margaret, Majeske Audrey, O'Brien Stephen J, Thomas David L, Carrington Mary

Abstract excerpt

Recovery from acute hepatitis B virus (HBV) infection requires a broad, vigorous T-cell response, which is enhanced in mice when chemokine receptor 5 (CCR5) is missing. To test the hypothesis that production of a nonfunctional CCR5 (CCR5Delta32 [a functionally null allele containing a 32-bp deletion]) increases the likelihood of recovery from hepatitis B in humans, we studied 526 persons from three cohorts in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17079285
DOI: 10.1128/JVI.01897-06
PMCID: PMC1797425

Genes

CCR5
CCR2
CCRL2

Provenance

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