Article
Increase in CCR5 Delta32/Delta32 genotype in multiple sclerosis.
Acta neurologica Scandinavica - 1 May 2004
Pulkkinen K, Luomala M, Kuusisto H, Lehtimäki T, Saarela M, Jalonen T O, Elovaara I
Abstract excerpt
Chemokines and their receptors participate in the development of multiple sclerosis (MS) by guiding immune cells into the brain tissue. A CCR5 Delta32 deletion mutation abolishes functional CCR5 on the cell surface and may reduce cell entry into the lesion sites. To analyse the significance of this mutation in MS, we compared the frequencies of CCR5 genotype in peripheral blood mononuclear cells from 89 MS...
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