Article
PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2009
Shimatani Kenichiro, Nakashima Yasuhiro, Hattori Masakazu, Hamazaki Yoko, Minato Nagahiro
Abstract excerpt
Although altered T cell function plays a part in immunosenescence, the mechanisms remain uncertain. Here we identify a bona fide age-dependent PD-1(+) memory phenotype (MP) CD4(+) T cell subpopulation that hardly proliferates in response to T cell receptor (TCR) stimulation and produces abundant osteopontin at the cost of typical T cell lymphokines. These T cells demonstrate impaired repopulation in Rag2(-/-)...
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