Article
Distribution and rearrangements of alleles of c-Ha-ras-1 protooncogene and their correlation with the development of lung, ovarian and thyroid cancers.
Neoplasma - 1 Jan 1990
Knyazev P G, Nikiforova I F, Serova O M, Pluzhnikova G F
Abstract excerpt
The protooncogene c-Ha-ras-1 locus in 84 cancer patients was examined for allelic restriction fragment length polymorphism. The distribution of four common c-Ha-ras-1 alleles (a1, a2, a3 and a4) in lung, ovarian and thyroid cancer patients was analyzed. In approximately half (8 out of 15) of lung and ovarian carcinomas possessing the a4 allele, alterations of the c-Ha-ras-1 locus (deletion of allele with the...
Topics
- Alleles
- Blotting, Southern
- Chromosome Deletion
- DNA, Neoplasm
- Female
- Gene Rearrangement
- Genes, ras
- Genotype
- Humans
- Lung Neoplasms
- Ovarian Neoplasms