Article
Ha-ras-1 alleles in Norwegian lung cancer patients.
Human genetics - 1 Nov 1990
Ryberg D, Tefre T, Ovrebø S, Skaug V, Stangeland L, Naalsund A, Baera R, Børresen A L, Haugen A
Abstract excerpt
We have examined DNA restriction fragment length polymorphisms (RFLP) of the Ha-ras-1 gene in DNA from 118 lung cancer patients and 123 unaffected controls. When DNA samples were digested with MspI/HpaII restriction endonucleases. Southern blot analysis demonstrated 4 common, 4 intermediate and 7 different rare alleles in the combined population after hybridization to the pGDa1 probe. Six of the rare alleles were...
Topics
- Alleles
- Blotting, Southern
- DNA Probes
- DNA, Neoplasm
- Genes, ras
- Genotype
- Humans
- Lung Neoplasms
- Polymorphism, Restriction Fragment Length