Article
[Alterations of c-myc and c-Ha-ras-1 oncogenes in human ovarian cancer].
Eksperimental'naia onkologiia - 1 Jan 1990
Serova O M, Nikiforova I F, Iurkova L E, Vinokurov V L, Kniazev P G
Abstract excerpt
Fourteen cases of the ovarian carcinoma (OC) were studied for alterations of c-myc and c-Ha-ras-1 oncogens. Amplification of c-myc was found in four aggressive and widespread OC. An increased frequency of one of the four common alleles of c-Ha-ras-1-allele A4-was determined in OC patients. Rearrangements of c-Ha-ras-1-allelic deletions and change in the allele fragment length-were found in all OC with A4 allele....
Topics
- Alleles
- Chromosome Mapping
- Female
- Genes, myc
- Genes, ras
- Genetic Markers
- Humans
- Ovarian Neoplasms
- Proto-Oncogene Proteins c-myc
- Proto-Oncogene Proteins p21(ras)