Article
Rare Ha-ras1 alleles and predisposition to testicular cancer.
International journal of cancer - 1 Apr 1993
Ryberg D, Heimdal K, Fosså S D, Børresen A L, Haugen A
Abstract excerpt
We have examined the restriction-fragment-length polymorphism (RFLP) of the VNTR region flanking the Ha-ras1 gene in genomic DNA from 348 testicular cancer patients and 343 healthy controls. When DNA samples were digested with MspI/HpaII, Southern blot analysis revealed 24 and 15 different alleles in the cancer and the control group respectively. The frequency of rare alleles among cases was significantly higher...
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