Article
Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients.
Environmental health perspectives - 1 Nov 1992
Ryberg D, Tefre T, Skaug V, Stangeland L, Ovrebø S, Naalsund A, Børresen A L, Haugen A
Abstract excerpt
We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot analysis revealed at least 22 different alleles, grouped according to their frequencies as common, intermediate, and rare. The frequency of rare alleles in lung cancer patients (16/428) is...
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