Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway.

Oncogene - 14 Jan 2010

Yoo Y, Ho H J, Wang C, Guan J-L

Abstract excerpt

Cofilin is a major regulator of actin dynamics involved in the regulation of cell spreading and migration through its actin depolymerizing and severing activities. v-Src is an activated Src tyrosine kinase and a potent oncogene known to phosphorylate a variety of cellular proteins in cell transfo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to HeLa Cells
Share to NIH 3T3 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Protein pp60(v-src)

Share to Proteasome Endopeptidase Complex

Share to Tyrosine

Share to Ubiquitin

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 19802004
DOI: 10.1038/onc.2009.319
PMCID: PMC2806939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19802004-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway.PMID 19802004Read ↗

Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75).Semantic proximity Read ↗

The actin-severing activity of cofilin is exerted by the interplay of three distinct sites on cofilin and essential for cell viability.Semantic proximity Read ↗

Src controls neuronal migration by regulating the activity of FAK and cofilin.Semantic proximity Read ↗

Unbalancing the Phosphatidylinositol-4,5-bisphosphate–Cofilin Interaction Impairs Cell SteeringSemantic proximity Read ↗

O-GlcNAcylation of cofilin promotes breast cancer cell invasion.Semantic proximity Read ↗

SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.Semantic proximity Read ↗

Epidermal growth factor-induced activation and translocation of c-Src to the cytoskeleton depends on the actin binding domain of the EGF-receptor.Semantic proximity Read ↗

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.Semantic proximity Read ↗

Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like.Semantic proximity Read ↗

Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth.Semantic proximity Read ↗

Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2.Semantic proximity Read ↗

Cofilin promotes actin polymerization and defines the direction of cell motility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.