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Article

Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75).

Cellular and molecular life sciences : CMLS - 1 Oct 2011

Pan Q, Qiao F, Gao C, Norman B, Optican L, Zelenka Peggy S

Abstract excerpt

The non-receptor tyrosine kinase Src is a critical regulator of cytoskeletal contraction, cell adhesion, and migration. In normal cells, Src activity is stringently controlled by Csk-dependent phosphorylation of Src(Y530), and by Cullin-5-dependent ubiquitinylation, which affects active Src(pY419) exclusively, leading to its degradation by the proteosome. Previous work has shown that Src activity is also limited...

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Identifiers

PMID: 21442427
DOI: 10.1007/s00018-011-0638-1
PMCID: PMC3167940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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