Article
Cofilin promotes actin polymerization and defines the direction of cell motility.
Science (New York, N.Y.) - 30 Apr 2004
Ghosh Mousumi, Song Xiaoyan, Mouneimne Ghassan, Sidani Mazen, Lawrence David S, Condeelis John S
Abstract excerpt
A general caging method for proteins that are regulated by phosphorylation was used to study the in vivo biochemical action of cofilin and the subsequent cellular response. By acute and local activation of a chemically engineered, light-sensitive phosphocofilin mimic, we demonstrate that cofilin polymerizes actin, generates protrusions, and determines the direction of cell migration. We propose a role for cofilin...
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