Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.

Molecular and cellular biology - 1 Apr 2002

Cary Leslie A, Klinghoffer Richard A, Sachsenmaier Christoph, Cooper Jonathan A

Abstract excerpt

Src family kinases (SFKs) are crucial for signaling through a variety of cell surface receptors, including integrins. There is evidence that integrin activation induces focal adhesion kinase (FAK) autophosphorylation at Y397 and that Src binds to and is activated by FAK to carry out subsequent phosphorylation events. However, it has also been suggested that Src functions as a scaffolding molecule through its SH2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Focal Adhesion Kinase 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Focal Adhesion Protein-Tyrosine Kinases

Share to Integrins

Share to Proto-Oncogene Proteins c-fyn

Share to src-Family Kinases

Share to src Homology Domains

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 11909938
DOI: 10.1128/MCB.22.8.2427-2440.2002
PMCID: PMC133722

Genes

SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.PMID 11909938Read ↗

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.Semantic proximity Read ↗

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.Semantic proximity Read ↗

Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth.Semantic proximity Read ↗

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration.Semantic proximity Read ↗

Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors.Semantic proximity Read ↗

A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly.Semantic proximity Read ↗

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.Semantic proximity Read ↗

Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration.Semantic proximity Read ↗

Integrin-mediated signal transduction in cells lacking focal adhesion kinase p125FAK.Semantic proximity Read ↗

Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75).Semantic proximity Read ↗

v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts.Semantic proximity Read ↗

Dynamics and mechanism of p130Cas localization to focal adhesions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.