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[The relationship of cytochrome P450 isoforms with the efficacy and safety of antipsychotic and antidepressant therapy].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2023

Bairamova S P, Pavlova O V, Shport S V, Gurina O I, Pavlov K A

Abstract excerpt

Cytochrome P450 (CYP450) is the leading enzyme in the biotransformation of most psychotropic drugs. CYP450 gene polymorphisms determine a patient's endophenotype with respect to the activity of enzymes of the family and affect the metabolism of prescribed antipsychotics and antidepressants. Categorizing patients by endophenotype during genotyping is likely to help simplify the selection of therapy in clinical...

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Identifiers

PMID: 37994887
DOI: 10.17116/jnevro202312311140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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