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Article

Flavin monooxygenase 3 (FMO3) polymorphism in a white population: allele frequencies, mutation linkage, and functional effects on clozapine and caffeine metabolism.

Clinical pharmacology and therapeutics - 1 Oct 1999

Sachse C, Ruschen S, Dettling M, Schley J, Bauer S, Müller-Oerlinghausen B, Roots I, Brockmöller J

Abstract excerpt

AIM: The flavin-containing monooxygenase 3 (FMO3) has been shown to be genetically polymorphic. In vitro, the enzyme contributes to the N-oxidation of clozapine, caffeine, and several other drugs. We therefore wanted to analyze population frequencies and allelic linkage of FMO3 mutations and their functional effect on the metabolism of clozapine and caffeine. METHODS: This study included 204 patients treated with...

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Source

Identifiers

PMID: 10546928
DOI: 10.1053/cp.1999.v66.a102203

Genes

FMO3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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