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Article

The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans.

Neural development - 2 Oct 2009

Norris Adam D, Dyer Jamie O, Lundquist Erik A

Abstract excerpt

BACKGROUND: While many molecules involved in axon guidance have been identified, the cellular and molecular mechanisms by which these molecules regulate growth cone morphology during axon outgrowth remain to be elucidated. The actin cytoskeleton of the growth cone underlies the formation of lamellipodia and filopodia that control growth cone outgrowth and guidance. The role of the Arp2/3 complex in growth cone...

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Identifiers

PMID: 19799769
DOI: 10.1186/1749-8104-4-38
PMCID: PMC2762468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans.PMID 19799769Read ↗

RACK-1 acts with Rac GTPase signaling and UNC-115/abLIM in Caenorhabditis elegans axon pathfinding and cell migration.Semantic proximity Read ↗

The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1.Semantic proximity Read ↗

The Arp2/3 activators WAVE and WASP have distinct genetic interactions with Rac GTPases in Caenorhabditis elegans axon guidance.Semantic proximity Read ↗

The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C. elegans.Semantic proximity Read ↗

Genetic analysis of growth cone migrations in Caenorhabditis elegans.Semantic proximity Read ↗

Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans.Semantic proximity Read ↗

UNC-115, a conserved protein with predicted LIM and actin-binding domains, mediates axon guidance in C. elegans.Semantic proximity Read ↗

unc-53 controls longitudinal migration in C. elegans.Semantic proximity Read ↗

UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.Semantic proximity Read ↗

Axon guidance mechanisms in Caenorhabditis elegans.Semantic proximity Read ↗

Rac GTPases control axon growth, guidance and branching.Semantic proximity Read ↗

Interactions of UNC-34 Enabled with Rac GTPases and the NIK kinase MIG-15 in Caenorhabditis elegans axon pathfinding and neuronal migration.Semantic proximity Read ↗

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