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Article

The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C. elegans.

Development (Cambridge, England) - 1 Feb 2003

Struckhoff Eric C, Lundquist Erik A

Abstract excerpt

Rac GTPases control cell shape by regulating downstream effectors that influence the actin cytoskeleton. UNC-115, a putative actin-binding protein similar to human abLIM/limatin, has previously been implicated in axon pathfinding. We have discovered the role of UNC-115 as a downstream cytoskeletal effector of Rac signaling in axon pathfinding. We show that unc-115 double mutants with ced-10 Rac, mig-2 Rac or...

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Identifiers

PMID: 12506000
DOI: 10.1242/dev.00300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C. elegans.PMID 12506000Read ↗

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