UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.

doi:10.1016/s0092-8674(00)81406-3

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Article

UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.

Cell - 20 Mar 1998

Steven R, Kubiseski T J, Zheng H, Kulkarni S, Mancillas J, Ruiz Morales A, Hogue C W, Pawson T, Culotti J

Abstract excerpt

unc-73 is required for cell migrations and axon guidance in C. elegans and encodes overlapping isoforms of 283 and 189 kDa that are closely related to the vertebrate Trio and Kalirin proteins, respectively. UNC-73A contains, in order, eight spectrin-like repeats, a Dbl/Pleckstrin homology (DH/PH)...

Topics

Animals
Axons
Blood Proteins
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Division
GTP Phosphohydrolases
GTPase-Activating Proteins
Gene Expression Regulation, Developmental
Genes, Reporter
Helminth Proteins
Molecular Sequence Data
Motor Neurons
Mutagenesis, Insertional

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Open in PubMed

Identifiers

PMID: 9529254
DOI: 10.1016/s0092-8674(00)81406-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9529254-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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