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The + 3010/C single nucleotide polymorphism (rs1710) at the HLA-G 3' untranslated region is associated with a short transcript exhibiting a deletion of 92 nucleotides.

Immunogenetics - 1 Apr 2023

Castelli Erick C, Paes Gabriela Sato, da Silva Isabelle Mira, Moreau Philippe, Donadi Eduardo A

Abstract excerpt

The physiological expression of HLA-G is mainly observed in the placenta, playing an essential role in maternal-fetal tolerance. Among the HLA-G mRNA alternative transcripts, the one lacking 92 bases at the HLA-G 3' untranslated region (3'UTR), the 92bDel transcript, is more stable, is associated with increased HLA-G soluble levels, and was observed in individuals presenting a 14 bp insertion (14 bp+) at the...

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PMID: 36879172
DOI: 10.1007/s00251-023-01297-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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