Article
The expression and functional activity of membrane-bound human leukocyte antigen-G1 are influenced by the 3'-untranslated region.
Human immunology - 1 Jul 2013
Svendsen Signe Goul, Hantash Basil M, Zhao Longmei, Faber Carsten, Bzorek Michael, Nissen Mogens Holst, Hviid Thomas Vauvert F
Abstract excerpt
Human Leukocyte Antigen (HLA)-G is an immunosuppressive molecule acting on both the innate and adaptive immune system. A 14 bp insertion/deletion polymorphism (rs66554220) in the 3'-untranslated region (3'UTR) of the HLA-G gene has been associated with a number of diseases, pregnancy complications, and graft rejection after organ transplantation. We have investigated the effect of HLA-G polymorphism in the 3'UTR...
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