Extreme discordant sib pairs for mapping quantitative trait loci in humans.

doi:10.1126/science.7777857

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Article

Extreme discordant sib pairs for mapping quantitative trait loci in humans.

Science (New York, N.Y.) - 16 Jun 1995

Risch N, Zhang H

Abstract excerpt

Analysis of differences between siblings (sib pair analysis) is a standard method of genetic linkage analysis for mapping quantitative trait loci, such as those contributing to hypertension and obesity, in humans. In traditional designs, pairs are selected at random or with one sib having an extr...

Topics

Alleles
Chromosome Mapping
Chromosomes, Human
Genetic Linkage
Genotype
Humans
Models, Genetic
Models, Statistical
Nuclear Family
Phenotype
Probability
Sample Size

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