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Article

Extreme discordant sib pairs for mapping quantitative trait loci in humans.

Science (New York, N.Y.) - 16 Jun 1995

Risch N, Zhang H

Abstract excerpt

Analysis of differences between siblings (sib pair analysis) is a standard method of genetic linkage analysis for mapping quantitative trait loci, such as those contributing to hypertension and obesity, in humans. In traditional designs, pairs are selected at random or with one sib having an extreme trait value. The majority of such pairs provide little power to detect linkage; only pairs that are concordant for...

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PMID: 7777857
DOI: 10.1126/science.7777857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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