Article
QTL mapping with discordant and concordant sibling pairs: new statistics and new design strategies.
Genetic epidemiology - 1 May 2005
Szatkiewicz Jin P, Feingold Eleanor
Abstract excerpt
The term "extreme discordant and concordant" (EDAC) sampling has been used to describe a variety of strategies for quantitative trait locus mapping using sibling pairs sampled from the corners of the bivariate trait distribution. The principle of the design is to gain efficiency by genotyping only the most informative of the available sibling pairs. EDAC-type designs have been studied in a number of papers, and...
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