Article
Selection of the most informative individuals from families with multiple siblings for association studies.
Genetic epidemiology - 1 May 2009
Liu Chunyu, Yang Qiong, Adrienne Cupples L, Meigs James B, Dupuis Josée
Abstract excerpt
Association analyses may follow an initial linkage analysis for mapping and identifying genes underlying complex quantitative traits and may be conducted on unrelated subsets of individuals where only one member of a family is included. We evaluate two methods to select one sibling per sibship wh...
Topics
- Blood Glucose
- Chromosome Mapping
- Data Interpretation, Statistical
- Epidemiologic Methods
- Female
- Genetics, Population
- Genome-Wide Association Study
- Humans
- Linkage Disequilibrium
- Male
- Models, Genetic
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- Siblings