Composite statistics for QTL mapping with moderately discordant sibling pairs.

doi:10.1086/302897

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Article

Composite statistics for QTL mapping with moderately discordant sibling pairs.

American journal of human genetics - 1 May 2000

Forrest W F, Feingold E

Abstract excerpt

Extreme discordant sibling-pair (EDSP) designs have been shown in theory to be very powerful for mapping quantitative-trait loci (QTLs) in humans. However, their practical applicability has been somewhat limited by the need to phenotype very large populations to find enough pairs that are extremely discordant. In this paper, we demonstrate that there is also substantial power in pairs that are only moderately...

Topics

Chromosome Mapping
Computer Simulation
Crosses, Genetic
Female
Gene Frequency
Genotype
Humans
Likelihood Functions
Lod Score
Male
Matched-Pair Analysis
Models, Genetic
Nuclear Family
Quantitative Trait, Heritable
Regression Analysis
Research Design
Sample Size
Software

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Identifiers

PMID: 10762549
DOI: 10.1086/302897
PMCID: PMC1378022

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