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Article

Considerations on study designs using the extreme sibpairs methods under multilocus oligogenic models.

Genetics - 1 Apr 2002

Gu Chi, Rao D C

Abstract excerpt

Several issues pertinent to study designs employing extreme sibpairs (ESP) methods to detect complex oligogenic quantitative trait loci (QTL) are investigated in the setting of genome-wide multipoint scans. We demonstrate that when stringent alpha-levels are imposed (e.g., alpha = 0.00022 as recommended by Landers and Kruglyak), the power to detect a susceptibility locus could drop from 83.6% under a one-locus...

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Identifiers

PMID: 11973325
DOI: 10.1093/genetics/160.4.1733
PMCID: PMC1462035

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