Article
Considerations on study designs using the extreme sibpairs methods under multilocus oligogenic models.
Genetics - 1 Apr 2002
Gu Chi, Rao D C
Abstract excerpt
Several issues pertinent to study designs employing extreme sibpairs (ESP) methods to detect complex oligogenic quantitative trait loci (QTL) are investigated in the setting of genome-wide multipoint scans. We demonstrate that when stringent alpha-levels are imposed (e.g., alpha = 0.00022 as recommended by Landers and Kruglyak), the power to detect a susceptibility locus could drop from 83.6% under a one-locus...
Topics
- Genotype
- Models, Genetic
- Nuclear Family
- Quantitative Trait, Heritable
- Research Design