Article
The diversity profile of TP53 is influenced by positive selection on the immediately upstream locus WDR79.
Human heredity - 1 Jan 2010
Alonso Santos, Izagirre Neskuts, López Saioa, Smith-Zubiaga Isabel, Hervella Montse, Boyano María Dolores, Arroyo-Berdugo Yoana, Gardeazabal Jesús, Díaz-Ramón José Luís, Sánchez Díez Ana, Careaga Jesus María, de la Rúa Concepción
Abstract excerpt
BACKGROUND/AIM: TP53 is an efficient central node in a signal transduction network that responds to minimize cancer. However, over 50% of tumors show some mutation in TP53. Thus, one might argue that this single central node network lacks robustness. Therefore, we wanted to investigate if natural selection has played a role in shaping the genomic region containing TP53. METHODS: We have analyzed the HapMap data...
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