Article
Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer.
International journal of cancer - 1 Dec 2007
Garcia-Closas Montserrat, Kristensen Vessela, Langerød Anita, Qi Ying, Yeager Meredith, Burdett Laurie, Welch Robert, Lissowska Jolanta, Peplonska Beata, Brinton Louise, Gerhard Daniela S, Gram Inger Torhild, Perou Charles M, Børresen-Dale Anne-Lise, Chanock Stephen
Abstract excerpt
Germline mutations in the tumor suppressor gene TP53 are associated with high incidence of early-onset malignancies, and somatic mutations occur in 20-40% of all breast cancer cases. We investigated the association of common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, with risk for breast cancer. Single nucleotide polymorphisms (SNPs) identified in a re-sequence analysis were genotyped in...
Topics
- Adaptor Proteins, Signal Transducing
- Adenosine Triphosphatases
- Breast Neoplasms
- Case-Control Studies
- Cation Transport Proteins
- Cell Adhesion Molecules, Neuronal
- Estrogens
- Female
- Gene Frequency