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Article

Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.

Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2012

Grizenkova Julia, Akhtar Shaheen, Hummerich Holger, Tomlinson Andrew, Asante Emmanuel A, Wenborn Adam, Fizet Jérémie, Poulter Mark, Wiseman Frances K, Fisher Elizabeth M C, Tybulewicz Victor L J, Brandner Sebastian, Collinge John, Lloyd Sarah E

Abstract excerpt

Prion diseases are fatal neurodegenerative disorders that include bovine spongiform encephalopathy (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans. They are characterized by long incubation periods, variation in which is determined by many factors including genetic background. In some cases it is possible that incubation time may be directly correlated to the level of gene expression....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22869728
DOI: 10.1073/pnas.1208917109
PMCID: PMC3427081

Genes

MRC2

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