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Article

Evidence for varied aetiologies regulating the transmission of prion disease: implications for understanding the heritable basis of prion incubation times.

PloS one - 2 Dec 2010

Iyegbe Conrad O, Abiola Oduola O, Towlson Chris, Powell John F, Whatley Steven A

Abstract excerpt

BACKGROUND: Transmissible Spongiform Encephalopathies (TSEs) are a group of progressive fatal neurodegenerative disorders, triggered by abnormal folding of the endogenous prion protein molecule. The encoding gene is a major biological factor influencing the length of the asymptomatic period after infection. It remains unclear the extent to which the variation between quantitative trait loci (QTLs) reported in...

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Identifiers

PMID: 21152031
DOI: 10.1371/journal.pone.0014186
PMCID: PMC2996284

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