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Article

HECTD2 is associated with susceptibility to mouse and human prion disease.

PLoS genetics - 1 Feb 2009

Lloyd Sarah E, Maytham Emma G, Pota Hirva, Grizenkova Julia, Molou Eleni, Uphill James, Hummerich Holger, Whitfield Jerome, Alpers Michael P, Mead Simon, Collinge John

Abstract excerpt

Prion diseases are fatal transmissible neurodegenerative disorders, which include Scrapie, Bovine Spongiform Encephalopathy (BSE), Creutzfeldt-Jakob Disease (CJD), and kuru. They are characterised by a prolonged clinically silent incubation period, variation in which is determined by many factors, including genetic background. We have used a heterogeneous stock of mice to identify Hectd2, an E3 ubiquitin ligase,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19214206
DOI: 10.1371/journal.pgen.1000383
PMCID: PMC2633041

Genes

HECTD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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