Article
Analysis of Ha-ras 1 allele frequencies in hereditary non-polyposis colorectal cancer.
Gut - 1 Mar 1995
Jeevaratnam P, Browett P J, Van de Water N S, Jass J R
Abstract excerpt
Restriction enzyme digests of genomic DNA show multiple alleles of common, intermediate, and rare frequencies at the minisatellite locus of Ha-ras. It has been suggested that a higher frequency of rare alleles is associated with the presence of colorectal and other types of cancer. This study investigated the distribution of Ha-ras alleles in 40 members of hereditary non-polyposis colorectal carcinoma (HNPCC)...
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