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Article

Genetic variations in the hypoxia-inducible factor-1alpha gene and lung cancer.

Experimental biology and medicine (Maywood, N.J.) - 1 Sept 2009

Konac Ece, Dogan Irem, Onen Hacer Ilke, Yurdakul Ahmet Selim, Ozturk Can, Varol Ayhan, Ekmecki Abdullah

Abstract excerpt

Hypoxia-inducible factor-1 (HIF-1), an important genetic component of angiogenesis, becomes stable as a response to tumor hypoxia and facilitates tumor survival. The polymorphisms of the HIF-1alphagene may cause changes in the activity of this protein, which serves as a transcription factor for many genes in tumorigenesis. In this study, we have investigated the relationship between seven HIF-1alphapolymorphisms...

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Source

Identifiers

PMID: 19546348
DOI: 10.3181/0902-RM-49

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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