[MDR (Multiple Drug Resistant) type of resistance to chemotherapy in clinical practice].

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Article

[MDR (Multiple Drug Resistant) type of resistance to chemotherapy in clinical practice].

Bulletin du cancer - 1 Aug 1996

Oudard S, Marie J P, Pujade Lauraine E

Abstract excerpt

Multifactorial resistance is the main mechanism of chemotherapy failure in cancers. Multidrug resistance (MDR) is related to the expression of a 170 kDa membrane glycoprotein, the so-called P-glycoprotein (P-gp). This protein is able to extrude drugs of various structures and mechanisms out of th...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Calcium Channel Blockers
Child, Preschool
Cyclosporine
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Drug Synergism
Gene Expression Regulation, Neoplastic
Humans
Immunosuppressive Agents
Mice
Phenotype
Verapamil

Source

Open in PubMed

Identifiers

PMID: 8869040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8869040-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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