Article
Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells.
Blood - 15 Nov 1993
te Boekhorst P A, de Leeuw K, Schoester M, Wittebol S, Nooter K, Hagemeijer A, Löwenberg B, Sonneveld P
Abstract excerpt
The expression of the MDR-1-encoded P-170 glycoprotein (P-170) associated with clinical multidrug resistance (MDR) was investigated in 52 consecutive patients with untreated acute myeloid leukemia (AML). P-170 expression was analyzed in correlation with CD34 expression and clinical response. Thirty of 52 patients expressed P-170 (58%). Eight of 30 P-170+ as compared with 16 of 22 P-170- patients achieved a...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antigens, CD
- Antigens, CD34
- Antineoplastic Combined Chemotherapy Protocols
- Carrier Proteins
- Daunorubicin
- Drug Resistance
- Flow Cytometry
- Humans
- Leukemia, Myeloid, Acute