Article
Multidrug resistance: focus in hematology.
Haematologica - 1 Jan 2000
Carulli G, Petrini M
Abstract excerpt
The appearance of chemoresistance is the most relevant limitation of chemotherapy. It has been shown that multidrug resistance (MDR) is frequently related to the expression of a membrane glycoprotein (P-170). This protein is able to bind ATP and leads to decreased accumulation of structurally unrelated antineoplastic drugs extensively used in the management of hematological patients. The availability of...
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